Journal
CANCER CELL
Volume 22, Issue 2, Pages 235-249Publisher
CELL PRESS
DOI: 10.1016/j.ccr.2012.06.013
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Funding
- National Cancer Institute [CA125255, CA030199, CA104898]
- American Cancer Society [IRG6000147]
- Bankhead-Coley Cancer Research Program [1BD11-34213]
- Florida Breast Cancer Foundation
- Department of Pathology, University of Alabama at Birmingham
- SBMRI
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We show that R-Ras, a small GTPase of the Ras family, is essential for the establishment of mature, functional blood vessels in tumors. The genetic disruption of R-Ras severely impaired the maturation processes of tumor vessels in mice. Conversely, the gain of function of R-Ras improved vessel structure and blood perfusion and blocked plasma leakage by enhanced endothelial barrier function and pericyte association with nascent blood vessels. Thus, R-Ras promotes normalization of the tumor vasculature. These findings identify R-Ras as a critical regulator of vessel integrity and function during tumor vascularization.
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