Journal
CANCER CELL
Volume 21, Issue 5, Pages 680-693Publisher
CELL PRESS
DOI: 10.1016/j.ccr.2012.03.043
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Funding
- National Institutes of Health (NIH) [T32 HL007627, 5T32CA09216-26, K01 AR055619, 1RO1CA154923, 1R21CA156056]
- Alex's Lemonade Stand Foundation
- Sarcoma Foundation of America
- American Cancer Society
- Harvard Stern Cell Institute
- Fundacao para a Ciencia e Tecnologia (Portuguese Foundation for Science and Technology) [SFRH/BD/51288/2010]
- [R01 CA122706]
- [K12 HD043494]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/51288/2010] Funding Source: FCT
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Embryonal rhabdomyosarcoma (ERMS) is an aggressive pediatric sarcoma of muscle. Here, we show that ERMS-propagating potential is confined to myf5+ cells and can be visualized in live, fluorescent transgenic zebrafish. During early tumor growth, myf5+ ERMS cells reside adjacent normal muscle fibers. By late-stage ERMS, myf5+ cells are reorganized into distinct regions separated from differentiated tumor cells. Time-lapse imaging of late-stage ERMS revealed that myf5+ cells populate newly formed tumor only after seeding by highly migratory myogenin+ ERMS cells. Moreover, myogenin+ ERMS cells can enter the vasculature, whereas myf5+ ERMS-propagating cells do not. Our data suggest that non-tumor-propagating cells likely have important supportive roles in cancer progression and facilitate metastasis.
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