Journal
CELL COMMUNICATION AND ADHESION
Volume 14, Issue 1, Pages 21-31Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15419060701224948
Keywords
adhesion; actin; hypoxia; invasion; melanoma-associated antigen family protein-D1 (MAGE-D1); migration
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Melanoma-associated antigen family protein-D1 ( MAGE-D1) is a recently identified p75 neurotrophin receptor intracellular binding protein and functions as an adaptor that mediates multiple signaling pathways, including D1x/Msx-mediated transcription. Here, a new regulatory function for MAGE-D1 in tumor cell motility and adhesion to endothelium is described. MAGE-D1 over-expression suppressed HeLa cell and BEL7402 cell migration, invasion, and adhesion to the monolayer of ECV304 cells. We also report that MAGE-D1 over-expression disrupted actin cytoskeleton rearrangement induced by hypoxia and down-regulated hypoxia inducible factor 1-dependent luciferase gene expression. These findings provide new insight into the ability of MAGE-D1 to suppress the motility and adhesion response of tumor cells by interfering with actin cytoskeleton reorganization and hypoxia inducible factor 1-dependent gene expression.
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