Journal
CANCER CELL
Volume 20, Issue 1, Pages 104-118Publisher
CELL PRESS
DOI: 10.1016/j.ccr.2011.05.027
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Funding
- ConCerN Foundation
- Melanoma Research Foundation
- Marc Jacobs Campaign
- NIH-NCI Cancer Center [P30CA016087]
- NIH [7 DP2 OD004711-02]
- National Cancer Center
- EMBO
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To metastasize, a tumor cell must acquire abilities such as the capacity to colonize new tissue and evade immune surveillance. Recent evidence suggests that microRNAs can promote the evolution of malignant behaviors by regulating multiple targets. We performed a microRNA analysis of human melanoma, a highly invasive cancer, and found that miR-30b/30d upregulation correlates with stage, metastatic potential, shorter time to recurrence, and reduced overall survival. Ectopic expression of miR-30b/30d promoted the metastatic behavior of melanoma cells by directly targeting the GaINAc transferase GALNT7, resulted in increased synthesis of the immunosuppressive cytokine IL-10, and reduced immune cell activation and recruitment. These data support a key role of miR-30b/30d and GaINAc transferases in metastasis, by simultaneously promoting cellular invasion and immunosuppression.
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