Journal
CANCER CELL
Volume 20, Issue 6, Pages 689-690Publisher
CELL PRESS
DOI: 10.1016/j.ccr.2011.11.022
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NCI NIH HHS [U54 CA163109] Funding Source: Medline
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Two recent papers in Cancer Cell (Lu et al., this issue of Cancer Cell, and Kang et al.) illustrate means whereby acquisition of VCAM-1 by tumor cells can promote metastasis. First, monocyte/macrophages expressing alpha 4 integrin bind VCAM-1 and provide survival signals enhancing establishment of metastases. Second, VCAM-1 allows dormant tumor cells to interact with osteoclasts, yielding paracrine signals and enhancing osteolytic metastatic growth.
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