Journal
CANCER CELL
Volume 20, Issue 6, Pages 691-693Publisher
CELL PRESS
DOI: 10.1016/j.ccr.2011.11.020
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In this issue of Cancer Cell, Mumm et al. demonstrate that pegylated IL-10 increases CD8(+) T cell numbers, IFN-gamma secretion, and cytotoxicity in established tumors, enhancing antigen presentation machinery and suppressing tumor growth. This approach may enhance T cell immune responses in cancers with reduced T cell infiltration.
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