Journal
CANCER CELL
Volume 20, Issue 4, Pages 418-420Publisher
CELL PRESS
DOI: 10.1016/j.ccr.2011.10.005
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Funding
- NCI NIH HHS [R01 CA129387-05, R01 CA129387] Funding Source: Medline
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Fumarate hydratase (FH) is a tumor suppressor, but how it acts is unclear. Two reports in this issue of Cancer Cell reveal that FH deficiency leads to succination of Keap1, stabilization of Nrf2, and induction of stress-response genes including HMOX1, which is important for the survival of FH-deficient cells.
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