Journal
CANCER CELL
Volume 17, Issue 4, Pages 362-375Publisher
CELL PRESS
DOI: 10.1016/j.ccr.2009.12.049
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Funding
- State of California
- University of California Industry-University [Bio05-10501]
- National Brain Tumor Society
- National Institutes of Health [CA 097257]
- Genentech
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The neural stem cell marker CD133 is reported to identify cells within glioblastoma (GBM) that can initiate neurosphere growth and tumor formation; however, instances of CD133(-) cells exhibiting similar properties have also been reported. Here, we show that some PTEN-deficient GBM tumors produce a series of CD133(+) and CD133(-) self-renewing tumor-initiating cell types and provide evidence that these cell types constitute a lineage hierarchy. Our results show that the capacities for self-renewal and tumor initiation in GBM need not be restricted to a uniform population of stemlike cells, but can be shared by a lineage of self-renewing cell types expressing a range of markers of forebrain lineage.
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