Journal
CANCER CELL
Volume 15, Issue 4, Pages 294-303Publisher
CELL PRESS
DOI: 10.1016/j.ccr.2009.02.022
Keywords
-
Categories
Funding
- Cancer Research UK
- The Institute of Cancer Research
- Breakthrough Breast Cancer
- Cancoropole ile-de-France
- National Health Service
Ask authors/readers for more resources
We show here that inducible expression of Braf(V600E) off the endogenous Braf gene in mouse melanocytes stimulates skin hyperpigmentation and the appearance of nevi harboring senescent melanocytes. Additionally, approximately 70% of Braf(V600E) mice develop melanomas that reproduce many of the cardinal histological and molecular features of human melanoma and whose cells can colonize the lungs of nude mice. We show that the tumor suppressor p16(INK4a) is not required to induce melanocyte senescence and that its loss is not required for tumor progression, although it does regulate tumor penetrance and latency. Thus, we have developed a mouse model of melanoma driven by Braf(V600E) expressed at physiological levels that reflects the genetics and pathology of the human disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available