Journal
CANCER CELL
Volume 15, Issue 3, Pages 165-166Publisher
CELL PRESS
DOI: 10.1016/j.ccr.2009.02.005
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The epithelial-specific cell adhesion molecule (EpCAM) modulates cell adhesion and proliferation. Its overexpression correlates with tumor cell proliferation, and EpCAM is a therapeutic target. In the February issue of Nature Cell Biology, Maetzel et al. demonstrate that proliferative responses to EpCAM require regulated intramembrane proteolysis and a nucleocytoplasmic intracellular domain fragment.
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