Journal
CANCER CELL
Volume 14, Issue 2, Pages 108-110Publisher
CELL PRESS
DOI: 10.1016/j.ccr.2008.07.012
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p53 is a pivotal bulwark against cancer, but exactly how it suppresses tumors remains elusive, in part because it modulates such diverse biological processes via so many downstream pathways. In a recent issue of Cell, Godar et al. (2008) now identify another string to p53's anticancer bow-repression of the CD44 cell-surface glycoproteins that coordinate many attributes of tumor progression.
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