Journal
PRION
Volume 1, Issue 1, Pages 3-8Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/pri.1.1.3969
Keywords
protein aggregation; simulations; amyloid fibril; oligomers; coarse-grained model; inhibitors
Categories
Funding
- NSERC
- FQRNT
- Canada Research Chair Program
- CNRS
- University Paris 7
- 6<SUP>th</SUP> European PCRD
- Alzheimer Society of Canada
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There is strong evidence that the oligomers of key proteins, formed during the early steps of aggregation, could be the primary toxic species associated with human neuro-degenerative diseases, such as Alzheimer's and prion diseases. Here, we review recent progress in the development of computational approaches in order to understand the structures, dynamics and free energy surfaces of oligomers. We also discuss possible research directions for the coming years.
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