3.9 Article

Effect of Aging On Angiogenesis and Arteriogenesis

Journal

CURRENT CARDIOLOGY REVIEWS
Volume 3, Issue 1, Pages 65-74

Publisher

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157340307779939970

Keywords

Angiogenic growth factors; collateral circulation; tissue ischemia; cardiovascular remodeling; therapeutic angiogenesis

Funding

  1. American Heart Association [HIH-HL37387]

Ask authors/readers for more resources

Aging is one of the important risk factors for cardiovascular disease. Cardiovascular structure and function are continually under the remodeling process as we age. Two forms of vascular remodeling are associated with physiological and pathological processes: (1) angiogenesis, a process of developing new capillaries from pre-existing capillaries, and (2) arteriogenesis, a process of forming functional collateral conduit arteries from the existing small arteries or arterioles in the matured individual. Current research suggests that aging may attenuate the both angiogenesis and arteriogenesis by producing less angiogenic stimulating cytokines, or by increasing expression of anti-angiogenic factors. Yet, aged individuals remain responsive to physical (e.g. exercise training) and/or biochemical stimuli (e.g. exogenous angiogenic growth factors) to improve the angiogenic and arteriogenic capacity. At present our knowledge of the biological mechanisms of aging and angiogenesis/arteriogenesis interactions is limited. NO-donors, single (FGF-2, VEGF, PDGFs) or combined angiogenic growth factors (VEGF, Ang-1) demonstrated efficacy in promoting collateral function in the ischemic tissues of aged animals. Future studies should aim at the basis of aging-impaired angiogenic capacity at molecular level, and search for more effective strategies for therapeutic angiogenesis to treat ischemic cardiovascular diseases.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

3.9
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available