Journal
CANCER CAUSES & CONTROL
Volume 24, Issue 1, Pages 13-25Publisher
SPRINGER
DOI: 10.1007/s10552-012-0078-8
Keywords
Diabetes; Risk factor; Cohort consortium; Pancreatic cancer
Funding
- National Cancer Institute, National Institutes of Health [HHSN261200800001E]
- Intramural Research Program of the National Cancer Institute
- U.S. Public Health Service [N01-CN-45165, N01-RC-45035, N01-RC-37004]
- National Institute of Aging [5U01AG018033]
- National Cancer Institute [CA105069, CA73790, P01CA087969, R01CA124908]
- European Commission: Public Health and Consumer Protection Directorate
- Ligue contre le Cancer
- Societe 3 M
- Mutuelle Generale de l'Education Nationale
- Institut National de la Sante et de la Recherche Medicale (INSERM) (France)
- German Cancer Aid, German Cancer Research Center, Federal Ministry of Education and Research (Germany)
- Danish Cancer Society (Denmark)
- Health Research Fund (FIS) of the Spanish Ministry of Health (Spain)
- Cancer Research UK
- Medical Research Council
- Stroke Association
- British Heart Foundation
- Department of Health, Food Standards Agency
- Wellcome Trust (United Kingdom)
- Greek Ministry of Health and Social Solidarity
- Hellenic Health Foundation
- Stavros Niarchos Foundation (Greece)
- Italian Association for Research on Cancer (AIRC) (Italy)
- Dutch Ministry of Public Health, Welfare and Sports
- Dutch Prevention Funds
- LK Research Funds
- Dutch ZON (Zorg Onderzoek Nederland) (the Netherlands)
- Swedish Cancer Society
- Swedish Scientific Council
- Regional Government of Skane and Vasterbotten (Sweden)
- World Cancer Research Fund (WCRF)
- National Institute of Environmental Health Sciences Center [ES000260]
- Intramural Research Program of National Cancer Institute (Division of Cancer Epidemiology and Genetics)
- National Heart, Lung, and Blood Institute [N01WH22110, 24152, 32100-2, 32105-6, 32108-9, 32111-13, 32115, 32118-32119, 32122, 42107-26, 42129-32, 44221]
- National Cancer Institute, National Institutes of Health
- [P01CA055075]
Ask authors/readers for more resources
Diabetes is a suspected risk factor for pancreatic cancer, but questions remain about whether it is a risk factor or a result of the disease. This study prospectively examined the association between diabetes and the risk of pancreatic adenocarcinoma in pooled data from the NCI pancreatic cancer cohort consortium (PanScan). The pooled data included 1,621 pancreatic adenocarcinoma cases and 1,719 matched controls from twelve cohorts using a nested case-control study design. Subjects who were diagnosed with diabetes near the time (< 2 years) of pancreatic cancer diagnosis were excluded from all analyses. All analyses were adjusted for age, race, gender, study, alcohol use, smoking, BMI, and family history of pancreatic cancer. Self-reported diabetes was associated with a forty percent increased risk of pancreatic cancer (OR = 1.40, 95 % CI: 1.07, 1.84). The association differed by duration of diabetes; risk was highest for those with a duration of 2-8 years (OR = 1.79, 95 % CI: 1.25, 2.55); there was no association for those with 9+ years of diabetes (OR = 1.02, 95 % CI: 0.68, 1.52). These findings provide support for a relationship between diabetes and pancreatic cancer risk. The absence of association in those with the longest duration of diabetes may reflect hypoinsulinemia and warrants further investigation.
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