Journal
CANCER CAUSES & CONTROL
Volume 22, Issue 4, Pages 529-540Publisher
SPRINGER
DOI: 10.1007/s10552-011-9729-4
Keywords
Estrogen metabolites; Tissue estrogen metabolism; Breast carcinogenesis
Funding
- NCI NIH HHS [P30 CA091842] Funding Source: Medline
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The role of estrogens in breast carcinogenesis has been investigated at the level of whole body (plasma) and cell (molecular, receptors, etc.). Growing attention focused on the breast tissue being an intracrine organ, with potentially important local estrogen production in the breast. However, very little is known about the local breast tissue estrogen levels. Understanding the role of the tissue estrogens in breast carcinogenesis might open new avenues in breast cancer prevention. This systematic review summarizes published studies that measured local estrogen levels in the breast and offers suggestions for strategies to fill gaps in our existing scientific knowledge.
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