Journal
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
Volume 27, Issue 9, Pages 606-613Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/cbr.2011.1150
Keywords
adipose-derived stem cells; apoptosis; conditioned medium; HCC
Categories
Funding
- National Natural Science Foundation of China [81171967]
- National Key Sci-Tech Special Project of China [2012ZX10002011-005]
- Projects of Xiamen Science and Technology Program [3502Z20114010]
- Public Health Department of Fujian Foundation for Young Scientists [2009-2-65]
Ask authors/readers for more resources
Hepatocellular carcinoma (HCC) is often diagnosed at an advanced stage, and over the past several decades, many researchers have worked to develop novel effective therapies for HCC patients. The functional contributions of mesenchymal stem cells to human malignancies, including HCC growth and progression, are controversial, and the potential mechanisms underlying these effects are not clear. The aim of this study was to investigate the effect of adipose-derived mesenchymal stem cells (ADSCs) on the growth of HCC cells. In this study, a conditioned medium from ADSCs (ADSC-CM) efficiently inhibited HCC cell proliferation and division, and induced HCC cell death through the downregulation of Akt signaling. These findings indicated that the ADSC-CM could inhibit HCC growth. Thus, the ADSC-CM is a good candidate for the treatment of HCC patients for whom no effective therapy is available.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available