Journal
CANCER BIOMARKERS
Volume 8, Issue 2, Pages 95-107Publisher
IOS PRESS
DOI: 10.3233/CBM-2011-0205
Keywords
Head and neck carcinoma; saliva; serum; proteomics; radiotherapy
Categories
Funding
- Proteomic Network of Sao Paulo state
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - CAPES
- Conselho Nacional de Pesquisas/CNPq
- FAPESP [2004/14846-0]
- FINEP [01.07.0290.00]
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Several body fluids have been evaluated as new sources for cancer biomarker discovery. In this context, salivary and serum proteomics seem promising diagnostic and predictive tools for head and neck diseases. In the present study, we performed a proteomic analysis of saliva and scrum from patients presenting head and neck squamous cell carcinoma (HNSCC) and compared the results before and after therapy. In saliva of cancer patients, we observed an altered protein profile, including over-expression of PLUNC and zinc-alpha-2-glycoprotein. Both proteins may contribute to control tumor growth and, therefore, represent targets for new analysis. We also detected serotransferrin and a modified transthyretin form with altered levels in serum from patients. Comparing preoperative and postreatment samples, the results showed that the protein profile after treatment reverted to a pattern closer to those observed for controls. These results add information on the role of secreted proteins in the cancer process and emphasize the potential of saliva and scrum analysis for diagnosis and monitoring of HNSCC.
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