Journal
CANCER BIOLOGY & THERAPY
Volume 15, Issue 3, Pages 256-262Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cbt.27823
Keywords
genomic instability; therapeutic approach; DNA damage; tumorigenesis; Jab1/CSN5
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Funding
- National Natural Science Foundation of China [81372816, 81071837]
- China Scholarship Council [2010638087]
- National Institutes of Health [1R01CA90853]
- Cancer Prevention Research Institute of Texas [RP120451-01]
- University Cancer Foundation via the Sister Institution Network Fund at the University of Texas MD Anderson Cancer Center
- MD Anderson's Cancer Center [CA016672]
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Jab1/CSN5 is a multifunctional protein that plays an important role in integrin signaling, cell proliferation, apoptosis, and the regulation of genomic instability and DNA repair. Dysregulation of Jab1/CSN5 activity has been shown to contribute to oncogenesis by functionally inactivating several key negative regulatory proteins and tumor suppressors. In this review, we discuss our current understanding of the relationship between Jab1/CSN5 and DNA damage and summarize recent findings regarding opportunities for and challenges to therapeutic intervention.
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