Role of microRNAs in breast cancer

MicroRNAs (miRNAs) are a class of post-transcriptional gene regulators with critical functions in normal cellular processes as well as disease processes. They are small molecules with 18 similar to 23 nucleotides in length. Since their early discovery in 1993, a large number of miRNAs have been characterized and analyzed to understand their pivotal role and their impact in a myriad of biological processes. Substantial research on miRNA highlights the involvement of these tiny RNAs in the etiopathogenesis of a variety of human diseases such as cancer, neuro-degenerative disorders, diabetes, cardiac hypertrophy and respiratory diseases. In this review, we update on recent advances of the emerging role of miRNAs in breast cancer and their clinical implications.