Journal
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Volume 29, Issue 3, Pages 322-325Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijantimicag.2006.10.003
Keywords
bactericidal effect; time-kill methodology; daptomycin; glycopeptides; linezolid
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The bactericidal activities of daptomycin, vancomycin, teicoplanin and linezolid at human peak free serum concentrations (C-max,(free)) were determined against Staphylococcus aureus (one methicillin-susceptible and two methicillin-resistant strains), Enterococcusfaecalis and Enterococcus faecium (one vancomycin-susceptible and one vancomycin-resistant strain of each). Daptomycin was rapidly bactericidal against 7/7 strains at C-max,(free), of 22.0 mg/L (corresponding to 63% protein binding) and against 3n strains at 4.8 mg/L (corresponding to 92% protein binding). Vancomycin (18.0 mg/L) was bactericidal against only two strains. Both teicoplanin (4.5 mg/L) and linezolid (10.4 mg/L) were consistently bacteriostatic. Daptomycin is a useful option for the treatment of Gram-positive infections owing to its strong bactericidal activity. (c) 2006 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
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