Journal
ANNALS OF THE RHEUMATIC DISEASES
Volume 66, Issue 3, Pages 417-418Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/ard.2006.055012
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The risk of major ulcer complications on treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) is known to increase exponentially with age. However, in a pooled analysis of 12 trial arms, the incidence of endoscopic ulcers on treatment with NSAID was found to increase with age in a roughly linear fashion. Thus, it is concluded that increasing age is associated with both more frequent and more serious NSAID gastropathy.
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