Journal
CANCER BIOLOGY & THERAPY
Volume 11, Issue 8, Pages 701-707Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cbt.11.8.14689
Keywords
cancer; receptor targeting; IGF; monoclonal antibodies; receptor tyrosine kinase inhibitors; anti-sense oligonucleotids; IGF binding proteins
Categories
Funding
- COMET Center Oncotyrol
- doctoral college program MCBO of the Austrian Science Founds
Ask authors/readers for more resources
During the last decades, changes in the insulin-like growth factor (IGF) signaling have been related to the pathogenesis of cancer. Therefore, IGFs became highly attractive therapeutic cancer targets. Several drugs including monoclonal antibodies (mAbs), small molecule tyrosine kinase inhibitors (RTKIs), antisense oligonucleotids (ASOs) and IGF-binding proteins (IGFBPs) targeting the IGF axis were developed. With over 60 ongoing clinical trials, the IGF1 receptor (IGF1R) is currently one of the most studied molecular targets in the field of oncology. In this review, we provide an overview on the IGF axis, its signaling pathways and its significance in neoplasia. We critically review the preclinical and clinical studies investigating the role of IGF1R as a cancer target and discuss preliminary results and possible limitations.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available