Journal
CANCER BIOLOGY & THERAPY
Volume 9, Issue 5, Pages 337-340Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cbt.9.5.11217
Keywords
MKP-1; MKP-2; MKP-3; dual specificity phosphatases; MAPK signaling; cancer
Categories
Funding
- NIH [R01 CA100073]
- NATIONAL CANCER INSTITUTE [R01CA100073] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Deregulation of cell signaling is a vital part of cancer development. The mitogen activated protein kinase (MAPK) family is involved in regulating both cell growth and cell death. This family of kinases is negatively regulated by mitogen activated protein kinase phosphatases (MKPs). MKPs are dual specificity phosphatases that target threonine and tyrosine residues that appear in a TXY motif. There are eleven members of the MKP family. Expression of MKPs has been shown to be altered in many different types of cancer. Most of what is known centers on MKP-1, MKP-2 and MKP-3. This review will focus on their role in cancer development and progression.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available