4.6 Article

Effects of child- and adolescent-onset endogenous Cushing syndrome on bone mass, body composition, and growth: A 7-year prospective study into young adulthood

Journal

JOURNAL OF BONE AND MINERAL RESEARCH
Volume 22, Issue 1, Pages 110-118

Publisher

AMER SOC BONE & MINERAL RES
DOI: 10.1359/JBMR.061010

Keywords

glucocorticoids; Cushing syndrome; bone and fat mass; growth; adiposity

Funding

  1. EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [ZIAHD008833, ZIAHD000618] Funding Source: NIH RePORTER
  2. EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [Z01HD008833, Z01HD000618] Funding Source: NIH RePORTER
  3. Intramural NIH HHS Funding Source: Medline

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The long-term effects on bone and fat mass in children with endogenous CS are unknown. In 14 children followed for 3-7 years into young adulthood after cure of CS, whereas bone mass largely recovered, persisting increases in total body and visceral fat suggests an increase risk of the metabolic syndrome.

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