Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 22, Issue 1, Pages 37-44Publisher
AMER SOC BONE & MINERAL RES
DOI: 10.1359/JBMR.061005
Keywords
renal cell carcinoma; bone; metastasis; TGF-beta 1; osteolysis
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Bone metastases develop in similar to 30% of patients with RCC, and the mechanisms responsible for this phenomenon are unknown. We found that TGF-beta 1 stimulation of RCC bone metastasis cells promotes tumor growth and bone destruction possibly by stimulating paracrine interactions between tumor cells and the bone.
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