Journal
CANCER BIOLOGY & THERAPY
Volume 8, Issue 11, Pages 1018-1023Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cbt.8.11.8375
Keywords
LRIG2; EGFR; RNAi; glioma; proliferation; invasion; adhesion
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Funding
- Chinese National Nature and Science fund [30500521, 30872653]
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The leucine-rich and immunoglobulin-like domains (LRIG) gene family contains LRIG1, 2 and 3. LRIG1 is a negative regulator of EGFR, but little is known about the function of LRIG2. To determine the role of LRIG2 in the progression of glioma, we performed RNA interference-mediated knockdown of LRIG2 in a human glioma cell line (GL15). Downregulation of LRIG2 expression resulted in: rapid EGF-mediated loss of EGFR; decreased proliferation; G(0)/G(1) arrest; increased spontaneous apoptosis; enhanced cell adhesion and increased invasion capability of GL15 cells in vitro. These findings indicate that LRIG2 possesses distinct functions compared with LRIG1 and validate the attractiveness of LRIG2 as a target in glioma therapy.
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