Journal
CANCER BIOLOGY & THERAPY
Volume 7, Issue 12, Pages 1885-1887Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cbt.7.12.6935
Keywords
Survivn; CD8 T cells; T-cell cloning; Cr-51-release assay; tumor immunology
Categories
Funding
- The Novo Nordisk Foundation
- Danish Cancer Society
- Danish Medical Research Council
- John and Birthe Meyer Foundation
- Herlev University Hospital
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Survivin is an attractive candidate for cancer immunotherapy since it is overexpressed in most common human cancers, poorly expressed in most normal adult tissues and is essential for cancer cell survival. Previously, we and others have demonstrated that survivin-specific immune responses are present in cancer patients. However, a significant limitation of these findings has been that antigen-specific lysis of tumors was achieved using polyclonal T-cell lines rather than a specific T-cell clone. In the present study we isolated and expanded a survivin specific cytotoxic T lymphocyte (CTL) clone from the peripheral blood of a cancer patient. The survivin specific CTL clone efficiently lysed a large panel of tumor cells of different origin, i.e., breast cancer, colon cancer and melanoma cells. The data support the notion that survivin may serve as a universal target antigen for anti-cancer immunotherapy.
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