Journal
CANCER AND METASTASIS REVIEWS
Volume 29, Issue 2, Pages 285-293Publisher
SPRINGER
DOI: 10.1007/s10555-010-9224-5
Keywords
Connective tissue growth factor; Lysyl oxidase; Metastasis; Hypoxia
Categories
Funding
- National Institutes of Health [RO1 CA-116685, PO1 CA-67166, T32 CA121940]
Ask authors/readers for more resources
Metastasis, the leading cause of cancer deaths, is an intricate process involving many important tumor and stromal proteins that have yet to be fully defined. This review discusses critical components necessary for the metastatic cascade, including hypoxia, inflammation, and the tumor microenvironment. More specifically, this review focuses on tumor cell and stroma interactions, which allow cell detachment from a primary tumor, intravasation to the blood stream, and extravasation at a distant site where cells can seed and tumor metastases can form. Central players involved in this process and discussed in this review include integrins, matrix metalloproteinases, and soluble growth factors/matrix proteins, including the connective tissue growth factor and lysyl oxidase.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available