Journal
CANCER AND METASTASIS REVIEWS
Volume 29, Issue 2, Pages 273-283Publisher
SPRINGER
DOI: 10.1007/s10555-010-9220-9
Keywords
Aging; Senescence; Cancer; Inflammation; Cytokines; Interleukins; Proliferation; Invasion; Migration
Categories
Funding
- National Institutes of Health [AG09909, AG017242, CA12654, AG025708, ES015566, AG025901, AG032117]
- Larry L. Hillblom Foundation
- DOE [AC03-76SF00098]
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Cellular senescence, which is associated with aging, is a process by which cells enter a state of permanent cell cycle arrest, therefore constituting a potent tumor suppressive mechanism. Recent studies show that, despite the beneficial effects of cellular senescence, senescent cells can also exert harmful effects on the tissue microenvironment. The most significant of these effects is the acquisition of a senescent-associated secretory phenotype (SASP), which entails a striking increase in the secretion of pro-inflammatory cytokines. Here, we summarize our knowledge of the SASP and the impact it has on tissue microenvironments and ability to stimulate tumor progression.
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