4.5 Review

Mitotic drivers-inhibitors of the Aurora B Kinase

Journal

CANCER AND METASTASIS REVIEWS
Volume 28, Issue 1-2, Pages 185-195

Publisher

SPRINGER
DOI: 10.1007/s10555-009-9184-9

Keywords

Aurora Kinase; Mitosis; Anti-mitotic; Cell-cycle; Cancer; Therapeutic

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Funding

  1. Cancer Research UK

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In this article we review the basis for current anti-mitotic, anti-cancer, therapy and the potential for Aurora B kinase inhibitors as a new differentiated class of agents-mitotic drivers. We review the current understanding of Aurora B inhibition from basic cell biology to inhibitors currently undergoing clinical trials.

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