Journal
CANCER AND METASTASIS REVIEWS
Volume 28, Issue 1-2, Pages 185-195Publisher
SPRINGER
DOI: 10.1007/s10555-009-9184-9
Keywords
Aurora Kinase; Mitosis; Anti-mitotic; Cell-cycle; Cancer; Therapeutic
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Funding
- Cancer Research UK
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In this article we review the basis for current anti-mitotic, anti-cancer, therapy and the potential for Aurora B kinase inhibitors as a new differentiated class of agents-mitotic drivers. We review the current understanding of Aurora B inhibition from basic cell biology to inhibitors currently undergoing clinical trials.
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