Journal
CANCER AND METASTASIS REVIEWS
Volume 27, Issue 2, Pages 169-178Publisher
SPRINGER
DOI: 10.1007/s10555-008-9125-z
Keywords
phosphatase; PP5; cancer; oxidative stress
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Funding
- NCI NIH HHS [CA 60750, R01 CA060750-15, R01 CA060750-13, R01 CA060750-14, R01 CA060750] Funding Source: Medline
- NCRR NIH HHS [P2P RR 016478, P20 RR016478] Funding Source: Medline
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Although the aberrant actions of protein kinases have long been known to contribute to tumor promotion and carcinogenesis, roles for protein phosphatases in the development of human cancer have only emerged in the last decade. In this review, we discuss the data obtained from studies examining the biological and pathological roles of a serine/threonine protein phosphatase, PP5, which suggest that PP5 is a potentially important regulator of both hormone- and stress-induced signaling networks that enable a cell to respond appropriately to genomic stress.
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