Journal
CANCER AND METASTASIS REVIEWS
Volume 27, Issue 4, Pages 679-690Publisher
SPRINGER
DOI: 10.1007/s10555-008-9152-9
Keywords
near infrared; MMP; in vivo imaging; MRI; PET; SPECT
Categories
Funding
- NIH [CA 60867, CA 84360]
- Vanderbilt-Ingram Cancer Center [P30CA068485]
- RLS
- NSF [0333392]
- Direct For Education and Human Resources
- Division Of Graduate Education [0333392] Funding Source: National Science Foundation
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Early detection of both primary tumors and metastatic disease remains a major challenge in the diagnosis and staging of cancer. The recognition of the role of MMPs in both the growth and metastasis of tumors has guided the development not only of therapeutic strategies utilizing synthetic, small-molecule MMP inhibitors (MMPIs), but has also catalyzed methods to detect and image tumors in vivo by means of tumor-associated proteolytic activity. These imaging approaches target MMPs involved in cancer progression via contrast agents linked to MMPIs or to MMP selective and specific substrates with sensitivity enhanced by amplification during enzymatic processing. This review draws attention to a variety of strategies utilized to image MMP activity in vivo.
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