Bicyclic guanidine-catalyzed enantioselective phospha-Michael reaction: synthesis of chiral beta-aminophosphine oxides and beta-aminophosphines

Chiral bicyclic guanidine has been found to catalyze the phospha-Michael reactions of diaryl phosphine oxide to nitroalkenes with high enantioselectivities, offering a direct methodology to prepare chiral beta-aminophosphine oxides and beta-aminophosphines.