Journal
JOURNAL OF VIROLOGY
Volume 81, Issue 1, Pages 430-433Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01567-06
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Kaposi's sarcoma (KS) is an AIDS-defining condition in individuals with human immunodeficiency virus type 1 infection. We investigated the phenotype and function of the NKG2C(+) NK cell population in individuals with AIDS and Kaposi's sarcoma. The staging of AIDS KS patients according to the AIDS Clinical Trial Group criteria revealed that patients with the S1 disease stage have a significantly higher proportion of NKG2C(+) cells than those with the SO disease stage. NKG2C(+) cells from SI-stage patients are highly enriched for the expression of KIR3DL1, are depleted of NKp46, and respond poorly to major histocompatibility complex class I-positive target cells. These data demonstrate a link between NK cell phenotype and function and disease prognosis in AIDS.
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