Journal
CRITICAL CARE MEDICINE
Volume 35, Issue 1, Pages 48-56Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.CCM.0000251132.10689.F3
Keywords
acute respiratory failure; genetic susceptibility; acute lung injury; molecular epidemiology
Categories
Funding
- NHLBI NIH HHS [K23 HL 67197, R01 HL 084060, R01 HL 60710, R01 HL084060, R01 HL060710, K23 HL067197] Funding Source: Medline
- NIMHD NIH HHS [L32 MD000662, L32 MD000662-02] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL084060, K23HL067197, R01HL060710] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Objective: The variant alleles in the mannose binding lectin-2 (MBL-2) gene have been associated with MBL deficiency and increased susceptibility to sepsis. We postulate that the variant MBL-2 genotypes are associated with increased susceptibility to and mortality in acute respiratory distress syndrome (ARDS). Design. Nested case-control study. Setting: Tertiary academic medical center. Patients: Two hundred and twelve Caucasians with ARDS and 442 controls genotyped for the variant X, D, B, and C alleles of codon -221, 52, 54, and 57, respectively. Interventions. None. Measurements and Main Results. Patients homozygous for the variant codon 54B allele (54BB) had worse severity of illness on admission (p =.007), greater likelihood of septic shock (p =.04), and increased odds of ARDS (adjusted odds ratio, 6.7; 95% confidence interval, 1.5-31) when compared with heterozygotes and homozygotes for the wild-type allele. This association with ARDS was especially strong among the 311 patients with septic shock (adjusted odds ratio, 12.0; 95% confidence interval, 1.9-74). Among the patients with ARDS, the 54BB genotype was associated with more daily organ dysfunction (p =.01) and higher mortality (adjusted hazard rate, 4.0; 95% confidence interval, 1.6-10). Development of ARDS and outcomes in ARDS did not vary significantly with variant alleles of codon -221, 52, and 57, but the power to detect an effect was limited secondary to the low allele frequencies. Conclusions: The MBL-2 codon 54BB genotype may be important in ARDS susceptibility and outcome. Additional studies are needed to confirm these findings in other populations.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available