Journal
CHEMICAL COMMUNICATIONS
Volume -, Issue 47, Pages 4978-4991Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b707257k
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Funding
- NATIONAL CANCER INSTITUTE [R01CA098945] Funding Source: NIH RePORTER
- NCI NIH HHS [1R01 CA098945] Funding Source: Medline
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Neutron capture therapy (NCT) is a binary radio-chemotherapeutic modality for the treatment of cancer. A major focus of NCT-related research is the development of novel tumor-selective agents that serve as the chemical component in NCT. Thymidine analogues substituted with a boron-containing carborane cluster at the N3 position, designated 3CTAs (3-carboranyl thymidine analogues), constitute one class of these new improved NCT agents. Their chemical, structural and biological properties are discussed in this Feature Article.
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