Synthesis and reactivity of [F-18]-N-fluorobenzenesulfonimide

A novel [F-18]NF reagent and two novel radiochemical transformations have been developed: [F-18]NFSi has been prepared from sodium dibenzenesulfonimide and reacted in the presence of silyl enol ethers and allylsilanes to deliver labelled fluorinated ketones and allylic fluorides respectively; the radiosynthesis of the fluorinated A ring of vitamin D-3 has also been completed with success.