Journal
JOURNAL OF VIROLOGY
Volume 81, Issue 2, Pages 568-574Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01512-06
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Funding
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS036592] Funding Source: NIH RePORTER
- NINDS NIH HHS [NS036592, R01 NS036592] Funding Source: Medline
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Mouse hepatitis virus (MHV) does not induce interferon (IFN) production in fibroblasts or bone marrow-derived dendritic cells. In this report, we show that the essential IFN-beta transcription factors NF-kappa B and IFN regulatory factor 3 are not activated for nuclear translocation and gene induction during infection. However, MHV was unable to inhibit the activation of these factors and subsequent IFN-beta production induced by poly(I:C). Further, MHV infection did not inhibit IFN-beta production mediated by known host pattern recognition receptors (PRRs) (RIG-I, Mda-5, and TLR3). These results are consistent with the notion that double-stranded RNA, produced during MHV infection, is not accessible to cellular PRRs.
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