4.7 Article

Probing the reaction mechanism of aristolochene synthase with 12,13-difluorofarnesyl diphosphate

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 40, Pages 4155-4157

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b709562g

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Funding

  1. EPSRC [EP/D069580/1] Funding Source: UKRI
  2. Engineering and Physical Sciences Research Council [EP/D069580/1] Funding Source: researchfish

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12,13- Difluorofarnesyl diphosphate, prepared using Suzuki Miyaura chemistry, is a potent inhibitor of aristolochene synthase ( AS), indicating that the initial cyclisation during AS catalysis generates germacryl cation in a concerted reaction.

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