Journal
JOURNAL OF BACTERIOLOGY
Volume 189, Issue 18, Pages 6635-6644Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.00640-07
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Genetic screens based on the use of MudJ-generated lac fusions permitted the identification of novel genes regulated by the Res signal transduction system in Salmonella enterica serovar Typhimurium. Besides genes that are also found in the Escherichia coli genome, our screens identified Salmonella-specific genes regulated by RcsB, including bapA, siiE, srfA, and srfB. Here we show that the srfABC operon is negatively regulated by RcsB and by PhoP. In vivo studies using mutants with constitutive activation of the Res and/or PhoPQ system suggested that there is an overlap between these regulatory systems in the control of Salmonella virulence.
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