Journal
FOOD CHEMISTRY
Volume 102, Issue 4, Pages 1042-1047Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2006.06.040
Keywords
Knipholone anthrone; Kniphofia foliosa; antioxidant activity; DPPH; reducing power; superoxide anion; hydroxyl radical; iron chelation; DNA damage
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Knipholone anthrone (KA), isolated from an Ethiopian medicinal plant, Kniphofia foliosa, Hochst (Asphodelaceae) has been shown to display a potent antiprotozoal activity and a relatively little cytotoxic effect on mammalin cells. In the present study, the antioxidant potential of KA was assessed using a variety of in vitro assay models. KA displayed a concentration-dependant scavenging effect against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. The IC(50) values obtained for KA and the positive control (-)-epicatechin (EC) in the DPPH assay were 22 +/- 11.5 and 8.7 +/- 0.9 mu M (mean +/- SEM; n = 3 separate experiments), respectively. KA displayed a better activity than EC in scavenging superoxide anions and preventing deoxyribose degradation by hydroxyl radicals. KA appeared to form a complex with Fe(2+), displayed a concentration-dependant reducing power, and also protected (at concentrations of 4.4 mu M and above) isolated DNA from damage induced by Fenton reaction-generated hydroxyl radicals. (c) 2006 Elsevier Ltd. All rights reserved.
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