Journal
NUCLEIC ACIDS RESEARCH
Volume 35, Issue 5, Pages 1452-1464Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkl1172
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Funding
- NATIONAL CANCER INSTITUTE [R01CA094926] Funding Source: NIH RePORTER
- NCI NIH HHS [R01 CA094926] Funding Source: Medline
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Eukaryotes and archaea use two sets of specialized ribonucleoproteins (RNPs) to carry out sequencespecific methylation and pseudouridylation of RNA, the two most abundant types of modifications of cellular RNAs. In eukaryotes, these protein-RNA complexes localize to the nucleolus and are called small nucleolar RNPs (snoRNPs), while in archaea they are known as small RNPs (sRNP). The C/D class of sno(s)RNPs carries out ribose2'-O-methylation, while the H/ACA class is responsible for pseudouridylation of their RNA targets. Here, we review the recent advances in the structure, assembly and function of the conserved C/D and H/ACA sno(s)RNPs. Structures of each of the core archaeal sRNP proteins have been determined and their assembly pathways delineated. Furthermore, the recent structure of an H/ACA complex has revealed the organization of a complete sRNP. Combined with current biochemical data, these structures offer insight into the highly homologous eukaryotic snoRNPs.
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