Journal
BIOLOGICAL PSYCHIATRY
Volume 61, Issue 1, Pages 13-16Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2006.01.023
Keywords
Affymetrix; Catechol-O-Methyl-Transferase; gene expression; genetic association; microarray; postmortem brain
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Funding
- NATIONAL INSTITUTE OF MENTAL HEALTH [P50MH060398] Funding Source: NIH RePORTER
- NIMH NIH HHS [P50MH60398] Funding Source: Medline
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Gene expression microarray analysis in postmortem brains is one of the fastest growing fields of psychiatric research. Here we show that common polymorphisms (SNTs) present on probe sets can masquerade as significant gene expression differences. After first observing this artifact in the Catechol-O-methyl transterase (COMT) gene, we replicate the finding in two additional genes predicted to show this artifact. Many Affymetrix chips contain thousands of SNPs that are both common and in the central probe region affecting hybridization, and thus have the potential to confound expression analysis.
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