Journal
PLANTA MEDICA
Volume 73, Issue 11, Pages 1192-1194Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2007-981597
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Ursolic acid (UA) is a pentacyclic triterpene acid naturally occurring in a number of foods and medicinal plants. it is one of the most promising chemopreventive agents and has been reported to induce apoptosis in many cancer cells. Here, we report that treatment with UA induces apoptosis in human leukemia K562 cells and down-regulates protein levels of bcl-xL. Treatment also increases phospho-JNK in a dose- and time-dependent manner but does not alter phospho-Erk1/2 and phospho-P38. These results suggest that JNK may participate in UA-induced apoptosis in K562 cells.
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