Journal
JOURNAL OF CLINICAL MICROBIOLOGY
Volume 45, Issue 9, Pages 3008-3014Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.02573-06
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In Europe, hemorrhagic fever with renal syndrome results mainly from infection with Puumala virus (PUUV) or Dobrava virus. For 31 patients from a hantavirus disease outbreak in Lower Bavaria, a district in southeast Germany, serodiagnosis was undertaken by enzyme-linked immuiniosorbent assay, immunofluorescence assay, and inummoblot analysis. In a few of these cases, however, PUUV-specific typing of antibodies by these standard assays failed and a virus neutralization assay under biosafet, level 3 conditions was required to verify the infection by this virus type. PUUV RNA was amplified by reverse transcription-PCR from acute-phase sera of three patients and was found to be very closely related to virus sequences obtained from bank voles (Clethrionomys glareolus) trapped in the same area. These findings link the outbreak with a novel PULTV lineage, Bavaria, circulating in the local rodent population. The Bavaria lineage associated with the outbreak is only distantly related to other PULTV lineages from Germany.
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