Journal
JOURNAL OF NEUROPHYSIOLOGY
Volume 97, Issue 6, Pages 4386-4389Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jn.01228.2006
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Funding
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [ZIAAA000407, Z01AA000407] Funding Source: NIH RePORTER
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Learning and memory are thought to involve activity-dependent changes in synaptic efficacy such as long- term potentiation (LTP) and long- term depression (LTD). Recent studies have indicated that endocannabinoid-dependent modulation of inhibitory transmission facilitates induction of hippocampal LTP and that endocannabinoids play a key role in certain forms of LTD. Here, we show that repetitive low-frequency synaptic stimulation (LFS) produces persistent up-regulation of endocannabinoid signaling at hippocampal CA1 GABAergic synapses. This LFS also produces LTD of inhibitory synapses and facilitates LTP at excitatory, glutamatergic synapses. These endocannabinoidmediated plastic changes could contribute to information storage within the brain.
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