Journal
CANCER
Volume 115, Issue 5, Pages 946-951Publisher
JOHN WILEY & SONS INC
DOI: 10.1002/cncr.24094
Keywords
breast cancer; radiotherapy; hormone receptor-negative; HER-2/neu; basal-like breast cancer
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Funding
- NCI NIH HHS [P30 CA006927-47S1, P30 CA006927-47S5, P30 CA006927-47S9, P30 CA006927-47S6, P30 CA006927-47, P30 CA006927-47S2, P30 CA006927, P30 CA006927-47S7, P30 CA006927-47S3, P30 CA006927-47S8, P30 CA006927-47S4] Funding Source: Medline
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BACKGROUND: The results of radiation on the local control of triple receptor-negative breast cancer (negative estrogen [ER], progesterone [PR], and HER-2/neu receptors) was studied. METHODS: Conservative surgery and radiation were used in 753 patients with T1-T2 breast cancer. Three groups were defined by receptor status: Group 1: ER or PR (+); Group 2: ER and PR (-) but HER-2 (+); and Group 3: triple-negative (TN). Factors analyzed were age, menopausal status, race, stage, tumor size, lymph node status, presentation, grade, extensive in situ disease, margins, and systemic therapy. The primary endpoint was 5-year locoregional recurrence (LRR) isolated or total with distant metastases. RESULTS: ER- and PR-negative patients were statistically significantly more likely to be black, have T2 disease, have tumors detectable on both mammography and physical examination, have grade 3 tumors, and receive chemotherapy. There were no significant differences noted with regard to ER- and PR- patients by HER-2 status. There was a significant difference noted in rates of first distant metastases (3%, 12%, and 7% for Groups 1, 2, and 3, respectively; P = .009). However, the isolated 5-year LRR was not significantly different (2.3%, 4.6%, and 3.2%, respectively; P = .36) between the 3 groups. CONCLUSIONS: Patients with TN breast cancer do not appear to be at a significantly increased risk for isolated LRR at 5 years and therefore remain appropriate candidates for breast conservation. Cancer 2009;115:946-51. (c) 2009 American Cancer Society.
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