Journal
JOURNAL OF APPLIED PHYSIOLOGY
Volume 102, Issue 4, Pages 1671-1676Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.01066.2006
Keywords
exercise; adenosine 5 '-monophosphate-activated protein kinase
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Glucose transport is an essential physiological process that is characteristic of all eukaryotic cells, including skeletal muscle. In skeletal muscle, glucose transport is mediated by the GLUT-4 protein under conditions of increased carbohydrate utilization. The three major physiological stimuli of glucose transport in muscle are insulin, exercise/contraction, and hypoxia. Here, the role of reactive oxygen species (ROS) in modulating glucose transport in skeletal muscle is reviewed. Convincing evidence for ROS involvement in insulin- and hypoxia-mediated transport in muscle is lacking. Recent experiments, based on pharmacological and genetic approaches, support a role for ROS in contraction-mediated glucose transport. During contraction, endogenously produced ROS appear to mediate their effects on glucose transport via AMP-activated protein kinase.
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