Journal
MOLECULAR IMMUNOLOGY
Volume 44, Issue 10, Pages 2497-2506Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2006.11.025
Keywords
cytokine receptor; Jak-Stat-Socs; inflammatory diseases
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The complexity of multicellular organisms is dependent on systems enabling cells to respond to specific stimuli. Cytokines and their receptors are one such system, whose perturbation can lead to a variety of disease states. This review represents an overview of our current understanding of the cytokine receptors, Janus kinases (Jaks), Signal transducers and activators of transcription (Slats) and Suppressors of cytokine signaling (Socs), focussing on their contribution to diseases of an immune or hematologic nature. (c) 2006 Elsevier Ltd. All rights reserved.
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