Journal
JOURNAL OF PHYSIOLOGY-LONDON
Volume 580, Issue 1, Pages 23-29Publisher
WILEY
DOI: 10.1113/jphysiol.2006.125302
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Funding
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [K22NS043365] Funding Source: NIH RePORTER
- NINDS NIH HHS [K22 NS043365] Funding Source: Medline
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Pronounced multivesicular release (MVR) occurs at the ribbon synapses of sensory neurones that signal via graded potential changes. As MVR increases the likelihood of postsynaptic receptor saturation, it is of interest to consider how sensory synapses overcome this problem and use MVR to encode signals of widely varying intensities. Here, I discuss three postsynaptic mechanisms that permit three different retinal synapses to utilize MVR.
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